Organic Synthesis : State of the Art 2011-2013

Contents Preface Organic Functional Group Interconversion and Protection 1. Functional Group Transformations May 14, 2012 2. Functional Group Interconversion October 22, 2012 3. Functional Group Interconversion May 13, 2013 4. Functional Group Interconversion October 28, 2013 5. Reduction and Oxidation May 21, 2012 6. Functional Group Oxidation and Reduction November 12, 2012 7. Functional Group Oxidation May 20, 2013 8. Functional Group Reduction May 27, 2013 9. Functional Group Protection May 28, 2012 10. Functional Group Protection October 29, 2012 11. Functional Group Protection June 12, 2013 12. Functional Group Protection November 11, 2013 Flow Methods 13. Develop of Flow Reactions September 24, 2012 14. Flow Chemistry March 25, 2013 15. Flow Chemistry September 30, 2013 C-H Functionalization 16. C-H Functionalization: The Ono/Kato/Dairi Synthesis of Fusiocca-1,10(14)-diene-3,8?,16-triol March 19, 2012 17. C-H Functionalization September 17, 2012 18. C-H Functionalization: The Hatakeyama Synthesis of (-)-Kaitocephalin January 28, 2013 19. C-H Functionalization September 16, 2013 20. Natural Product Synthesis by C-H Functionalization: (?-Allokainic Acid (Wee), (-)-Cameroonan-7?-ol (Taber), (+)-Lithospermic Acid (Yu), (-)-Manabacanine (Kroutil), Streptorubin B and Metacycloprodigiosin (Challis) January 30, 2012 21. Natural Product Synthesis by C-H Functionalization: (-)-Zampanolide (Ghosh), Muraymycin D2 (Ichikawa), (+)-Sundiversifolide (Iwabuchi), (+)-Przewalskin B (Zhang/Tu), Artemisinin (Wu) June 11, 2012 Carbon-Carbon Bond Construction 22. Carbon-Carbon Bond Formation: The Bergman Synthesis of (+)-Fuligocandin B March 12, 2012 23. C-C Bond Formation: The Petrov Synthesis of Combretastatin A-4 June 18, 2012 24. Carbon-Carbon Bond Construction: The Baran Synthesis of (+)-Chromazonarol March 11, 2013 25. Carbon-Carbon Bond Construction July 29, 2013 26. Reactions Involving C-C Bond Cleavage September 23, 2013 Reactions of Alkenes 27. Reactions of Alkenes: The RajanBabu Synthesis of Pseudopterosin G-J Aglycone Dimethyl Ether March 26, 2012 28. Reactions of Alkenes September 10, 2012 29. Reactions of Alkenes March 18, 2013 30. Synthesis and Reactions of Alkenes September 9, 2013 31. Advances in Alkene Metathesis: The Kobayashi Synthesis of (+)-TMC-151C January 23, 2012 Enantioselective Construction of Acyclic Stereogenic Centers 32. Enantioselective Synthesis of Alcohols and Amines: The Ichikawa Synthesis of (+)-Geranyllinaloisocyanide February 13, 2012 33. Enantioselective Synthesis of Alcohols and Amines: The Fujii/Ohno Synthesis of (+)-Lysergic Acid July 16, 2012 34. Asymmetric C-Heteroatom Bond Formation February 11, 2013 35. Construction of Single Stereocenters July 15, 2013 36. Enantioselective Construction of Alkylated Centers: The Shishido Synthesis of (+)-Helianane February 20, 2012 37. Enantioselective Synthesis of Alkylated Centers: The Fukuyama Synthesis of (-)-Histrionicotoxin July 23, 2012 38. Asymmetric C-C Bond Formation February 18, 2013 39. Arrays of Stereogenic Centers: The Davies Synthesis of Acosamine February 27, 2012 40. Construction of Alkylated Stereocenters: The Deng Synthesis of (-)-Isoacanthodoral July 8, 2013 41. Arrays of Stereogenic Centers: The Barker Synthesis of (+)-Galbelgin July 30, 2012 42. Arrays of Stereogenic Centers: The Carbery Synthesis of Mycestericin G February 25, 2013 43. Construction of Stereochemical Arrays July 22, 2013 Construction of C-O Rings 44. Stereoselective C-O Ring Construction: The Keck Synthesis of Bryostatin 1 January 9, 2012 45. C-O Ring Construction: The Georg Synthesis of Oximidine II April 9, 2012 46. C-O Ring Construction: The Reisman Synthesis of (-)-Acetylaranotin January 14, 2013 47. C-O Ring Formation April 8, 2013 48. C-O Ring Construction: (+)-Varitriol (Liu), (+)-Isatisine A (Panek), (+)-Herboxidiene / GEX1A (Ghosh), (-)-Englerin A (Chain), Platensimycin (Lear/Wright) January 16, 2012 49. C-O Natural Products: (-)-Hybridalactone (F?stner), (+)- Anthecotulide (Hodgson), (-)-Kumausallene (Tang), (?-Communiol E (Kobayashi), (-)-Exiguolide (Scheidt), Cyanolide A (Rychnovsky) April 16, 2012 50. C-O Ring Containing Natural Products January 21, 2013 51. Total Synthesis of C-O Ring-Containing Natural Products April 15, 2013 Construction of C-N Rings 52. C-N Ring Construction: The Harrity Synthesis of Quinolizidine (-)-217A April 23, 2012 53. New Methods for C-N Ring Construction November 19, 2012 54. C-N Ring Construction: The Fujii/Ohno Synthesis of (-)-Quinocarcin April 22, 2013 55. C-N Ring Construction: The Hoye Synthesis of (?-Leuconolactam November 18, 2013 56. Alkaloid Synthesis: (-)-?-Kainic Acid (Cohen), Hyacinthacine A2 (Fox), (-)-Agelastatin A (Hamada), (+)-Luciduline (Barbe), (+)-Lunarine (Fan), (-)-Runanine (Herzon) April 30, 2012 57. Alkaloid Synthesis: Indolizidine 207A (Shenvi), (-)-Acetylaranotin (Reisman), Flinderole A (May), Isohaouamine B (Trauner), (-)-Strychnine (MacMillan) November 26, 2012 58. Alkaloid Synthesis: (+)-Deoxoprosopinine (Krishna), Alkaloid (-)-205B (Micalizio), FR901483 (Huang), (+)-Ibophyllidine (Kwon), (-)-Lycoposerramine-S (Fukuyama), (?-Crinine (Lautens) April 29, 2013 59. Alkaloid Synthesis: Lycoposerramine Z (Bonjoch), Esermethole (Shishido), Goniomitine (Zhu), Grandisine (Taylor), Reserpine (Jacobsen) November 25, 2013 Substituted Benzene Derivatives 60. Substituted Benzenes: The Reddy Synthesis of Isofregenedadiol June 25, 2012 61. Substituted Benzenes: The Alvarez-Manzaneda Synthesis of (-)-Akaol A October 8, 2012 62. Substituted Benzenes: The Subba Reddy Synthesis of 7-Desmethoxyfusarentin June 17, 2013 63. Substituted Benzenes: The Gu Synthesis of Rhazinal October 14, 2013 Heteroaromatic Derivatives 64. Heteroaromatic Construction: The Sperry Synthesis of (+)-Terreusinone July 9, 2012 65. Heteroaromatic Construction: The Sato Synthesis of (-)-Herbindole October 15, 2012 66. Advances in Heterocyclic Aromatic Construction June 24, 2013 67. Synthesis of Heteroaromatics October 21, 2013 Organocatalyzed C-C Ring Construction 68. Organocatalytic Carbocyclic Construction: The You Synthesis of (-)-Mesembrine August 20, 2012 69. Organocatalyzed Carbocyclic Construction: (+)-Roseophilin (Flynn) and (+)-Galbulin (Hong) December 10, 2012 70. Organocatalytic C-C Ring Construction: Prostaglandin F2? (Aggarwal) August 12, 2013 71. Organocatalyzed C-C Ring Construction: The Hayashi Synthesis of PGE1 Me Ester December 16, 2013 Metal-Mediated C-C Ring Construction 72. Metal-Mediated Carbocyclic Construction: The Chen Synthesis of Ageliferin August 13, 2012 73. Metal-Mediated Carbocyclic Construction: The Whitby Synthesis of (+)-Mucosin December 17, 2012 74. Metal-Mediated C-C Ring Construction: (+)-Shiromool (Baran) August 19, 2013 75. Metal-Mediated Ring Construction: The Hoveyda Synthesis of (-)-Nakadomarin A December 9, 2013 Intermolecular and Intramolecular Diels-Alder Reactions 76. Intramolecular Diels-Alder Cycloaddition: 7-Isocyanoamphilecta-11(20),15-diene (Miyaoka), (-)-Scabronine G (Kanoh), Basiliolide B (Stoltz), Hirsutellone B (Uchiro), Echinopine A (Chen) August 27, 2012 77. Diels-Alder Cycloaddition: Fawcettimine (Williams), Apiosporic Acid (Helmchen), Marginatone (Abad-Somovilla), Okilactomycin (Hoye), Vinigrol (Barriault), Plakotenin (Bihlmeier/Klopper) December 24, 2012 78. Diels-Alder Cycloaddition: Defucogilvocarcin V (Bodwell), (+)-Carrisone (Danishefsky), (+)-Fusarisetin A (Theodorakis), 9?-Presilphiperfolan-1?-ol (Stoltz), 7-Isocyano-11(20), 14-epiamphilectadiene (Shenvi) August 26, 2013 79. Diels-Alder Cycloaddition: (+)-Armillarivin (Banwell), Gelsemiol (Gademann), (+)-Frullanolide (Liao), Myceliothermophin A (Uchiro), Peribysin E (Reddy), Caribenol A (Li/Yang) December 23, 2013 Stereocontrolled C-C Ring Construction 80. Chloranthalactone (Liu), Rumphellaone A (Kuwahara), Lactiflorin (Bach), Echinosporin (Hale), Harveynone (Taylor), (6,7-deoxy)-Yuanhuapin (Wender) December 31, 2012 81. Other Methods for C-C Ring Construction: The Liang Synthesis of Echinopine B December 30, 2013 Classics in Total Synthesis 82. The Reisman Synthesis of (+)-Salvileucalin B January 2, 2012 83. The Theodorakis Synthesis of (-)-Jiadifenolide February 6, 2012 84. The Yamashita/Hirama Synthesis of Cortistatin A March 5, 2012 85. The Reisman Synthesis of (-)-Maoecrystal Z April 2, 2012 86. The Tan/Chen/Yang Synthesis of Schindilactone A May 7, 2012 87. The Garg Synthesis of (-)-N-Methylwelwitindolinone C June 4, 2012 88. The Krische Synthesis of Bryostatin 7 July 2, 2012 89. The Fukuyama Synthesis of Gelsemoxonine August 6, 2012 90. The Carreira Synthesis of (+)-Daphmanidin E September 3, 2012 91. The Qin Synthesis of (+)-Gelsemine October 1, 2012 92. The Carreira Synthesis of Indoxamycin B November 5, 2012 93. The Nicolaou/Li Synthesis of Tubingensin A December 3, 2012 94. The Thomson Synthesis of (-)-GB17 January 7, 2013 95. The Li Synthesis of (-)-Fusarisetin A February 4, 2013 96. The Carreira Synthesis of (-)-Dendrobine March 4, 2013 97. The Vanderwal Synthesis of Echinopine B April 1, 2013 98. The Dixon Synthesis of Manzamine A May 6, 2013 99. The Williams Synthesis of (-)-Khayasin June 3, 2013 100. The Kuwahara Synthesis of Paspalinine July 1, 2013 101. The Ma Synthesis of Gracilamine August 5, 2013 102. The Carreira Synthesis of (?-Gelsemoxonine September 2, 2013 103. The Evans Synthesis of (-)-Nakadomarin A October 7, 2013 104. The Procter Synthesis of (+)-Pleuromutilin November 4, 2013 105. The Harran Synthesis of (+)-Roseophilin December 2, 2013

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