Pharmacy Archives - PaiBros.in

Name Reactions: A Collection of Detailed Mechanisms and Synthetic Applications

adminpai — Thu, 02 Sep 2021 17:19:04 +0000

In this fifth edition of Jack Jie Li’s seminal “Name Reactions”, the author has added twenty-seven new name reactions to reflect the recent advances in organic chemistry. As in previous editions, each reaction is delineated by its detailed step-by-step, electron-pushing mechanism and supplemented with the original and the latest references, especially from review articles. Now with addition of many synthetic applications, this book is not only an indispensable resource for advanced undergraduate and graduate students, but is also a good reference book for all organic chemists in both industry and academia.

Unlike other books on name reactions in organic chemistry, Name Reactions, A Collection of Detailed Reaction Mechanisms and Synthetic Applications focuses on the reaction mechanisms. It covers over 320 classical as well as contemporary name reactions.

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DRUGS IN USE

adminpai — Thu, 02 Sep 2021 17:17:26 +0000

This work is intended to offer guidance to pharmacists who require to bridge the gap between their theoretical knowledge and its practical application to individual patients. A series of case studies drawn from all over the UK is presented in a question and answer format. The topics incorporated in the book cover a wide area including both commonly encountered and problematic diseases and types of therapy in which major advances have been achieved in recent years. By presenting a case and using the question and answer format, the authors demonstrate how they would select the most appropriate therapy for the patient under discussion and how they would monitor the chosen therapy by observing the patient and interpreting the results of laboratory tests, including serum drug concentrations. They also illustrate how skills such as formulation, the taking of medical histories and counselling can be used by pharmacists to improve patient care. The detailed index to disease states and drug names is intended to facilitate the use of the book as a teaching aid

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Structure Based Drug Discovery

adminpai — Thu, 02 Sep 2021 17:16:50 +0000

This book describes some of the most exciting developments for the discovery of new drugs, such as Fragment-based methods. It contains the latest developments in technologies that can be used to obtain the 3-D structures. This book includes experimental approaches using X-ray crystallography and NMR for Fragment-based screening as well as other biophysical methods for studying protein/ligand interactions.

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Principles of Immunopharmacology

adminpai — Thu, 02 Sep 2021 17:16:37 +0000

ISBN: 9788181286086

Author/Editor: Nijkamp

Publisher: Springer

Year: 2007

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MODERN METHODS OF DRUG DISCOVERY

adminpai — Thu, 02 Sep 2021 17:16:26 +0000

ISBN: 9788184891508

Author/Editor: Hillisch

Publisher: Springer

Year: 2009

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Privileged Scaffolds in Medicinal Chemistry: Design, Synthesis, Evaluation

adminpai — Thu, 02 Sep 2021 17:14:07 +0000

One strategy to expedite the discovery of new drugs, a process that is somewhat slow and serendipitous, is the identification and use of privileged scaffolds. This book covers the history of the discovery and use of privileged scaffolds and addresses the various classes of these important molecular fragments.
The first of the benzodiazepines, a class of drugs that is powerful for treating anxiety, may not have been discovered had it not been for a chance experiment on the contents of a discarded flask found during a lab clean-up. Some years later, scientists discovered that benzodiazepine derivatives were also effective in treating other diseases. This class of molecules was the first to be described as privileged in the sense that it is especially effective at altering the course of disease. Other privileged molecular structures have since been discovered, and since these compounds are so effective at interacting with numerous classes of proteins, they may be an effective starting point to look for new drugs against the supposedly “undruggable” proteins.
Following introductory chapters presenting an overview, a historical perspective and the theoretical background and findings, main chapters describe the structure of privileged structures in turn and discuss major drug classes associated with them and their syntheses. This book provides comprehensive coverage of the subject through chapters contributed by expert authors from both academia and industry and will be an excellent reference source for medicinal chemists of a range of disciplines and experiences.

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Quantitative In Silico Chromatography: Computational Modelling of Molecular Interactions

adminpai — Thu, 02 Sep 2021 17:14:07 +0000

The coupling of mass spectrometry or nuclear magnetic resonance to chromatography has broadened the possibilities for determining organic reaction mechanisms. And while many results have been published reporting these, even more can be achieved through modern computational methods. Combining computational and theoretical techniques with advanced chromatographic methods offers a powerful tool for quantitatively determining molecular interactions .

This book presents the possibilities for characterising biological applications by combining analytical and computational chemistries. Written by the author of “HPLC: A Practical Guide” (RSC, 1999), the book examines not only the behaviour of biological reactions per se, but also describes the behaviour of biological molecules in chromatography systems. Various software packages are reviewed, and most computations can be performed on a standard PC using accessible software. Consideration is given to a variety of chromatographic techniques and strategies for high-sensitivity detection are presented.

The first book of its kind, it will inspire readers to explore the possibilities of combining these techniques in their own work, whether at an industrial or academic level.

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Metabolic Profiling: Disease and Xenobiotics

adminpai — Thu, 02 Sep 2021 17:14:04 +0000

Multivariate analysis of the multi-component analytical profiles of carefully collected biofluid and/or tissue biopsy specimens can provide a ‘fingerprint’ of their biomolecular/metabolic status. Therefore, if applied correctly, valuable information regarding disease indicators, disease strata and sub-strata and disease activities can be obtained.

This exemplary new book highlights applications of these techniques in the areas of drug therapy and toxicology, cancer, obesity and diabetes, as well as outlining applications to cardiovascular, infectious, inflammatory and oral diseases in detail. The book gives particular reference to cautionary measures that must be applied to the diagnosis and classification of these conditions or physiological criteria. Comprehensively covering a wide range of topics, of particular interest is the focus on experimental design and ‘rights and wrongs’ of the techniques commonly applied by researchers, and the very recent development of powerful ‘Pattern Recognition’ techniques.

The book provides a detailed introduction to the area, applications and common pitfalls of the techniques discussed before moving into detailed coverage of specific disease areas, each highlighted in individual chapters. This title will provide an invaluable resource to Medicinal chemists, Biochemists and toxicologists working in industry and academia.

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Ion Channel Drug Discovery

adminpai — Thu, 02 Sep 2021 17:13:57 +0000

Ion channel drug discovery is a rapidly evolving field fuelled by recent, but significant, advances in our understanding of ion channel function combined with enabling technologies such as automated electrophysiology. The resurgent interest in this target class by both pharmaceutical and academic scientists was clearly highlighted by the over-subscribed RSC/BPS ‘Ion Channels as Therapeutic Targets’ symposium in February 2009.

This book builds on the platform created by that meeting, covering themes including advances in screening technology, ion channel structure and modelling and up-to-date case histories of the discovery of modulators of a range of channels, both voltage-gated and non-voltage-gated channels. The editors have built an extensive network of contacts in the field through their first-hand scientific experience, collaborations and conference participation and the organisation of the meeting at Novartis, Horsham, increased the network enabling the editors to draw on the experience of eminent researchers in the field. Interest and investment in ion channel modulation in both industrial and academic settings continues to grow as new therapeutic opportunities are identified and realised for ion channel modulation. This book provides a reference text by covering a combination of recent advances in the field, from technological and medicinal chemistry perspectives, as well as providing an introduction to the new ‘ion channel drug discoverer’. The book has contributions from highly respected academic researchers, industrial researchers at the cutting edge of drug discovery and experts in enabling technology. This combination provides a complete picture of the field of interest to a wide range of readers.

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Macrocycles in Drug Discovery

adminpai — Thu, 02 Sep 2021 17:13:57 +0000

This book reviews macrocycles in drug discovery, both those of natural origin and semi-synthetic derivatives of natural products, and those designed and synthesized based on principles of medicinal chemistry.
The medicinal chemistry of macrocyclic natural products is interesting in itself, but lessons learned from these compounds, in terms of the relationship between structure and desirable physicochemical properties, are now informing the design of fully synthetic macrocyclic drug candidates against a variety of targets including kinases, ATPases, proteases, GPCRs and others. Furthermore, as more non-classical drug targets, such as protein-protein interactions, are pursued in the pharmaceutical industry, macrocyclic molecules are generating increasing interest as they offer a way to provide drug-protein interactions that cover a larger surface area than traditional small molecules.
A variety of macrocycles have become important drugs or have been identified as leads to marketed drugs. This text will discuss these compounds, their pharmacology and synthesis, in the context of their broad chemotype as compounds composed of large rings. Providing a wide reaching review of this important area in a single volume, this book will be of interest to biochemists, pharmaceutical scientists and medicinal chemists working in industry or academia.

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