Handbook of Biotransformations of Aromatic Compounds
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ISBN: 9780415271769
Author/Editor: B.L. Goodwin
Publisher: CRC Press
Year: 2004
1 in stock (can be backordered)
Description
Understanding the biotransformations of aromatic compounds and how they metabolize in animals, plants, and microbes, is central to the applications in a wide range of industries, such as the design and testing of natural and synthetic pharmaceuticals, oil refining, the development of agrochemicals, bioremediation, and for use in functional genomics and xenobiotics.
Presenting the most complete resource of its kind, the Handbook of Biotransformations of Aromatic Compounds examines 20,000 aromatic compounds researched since 1972, and assembled from all the major, relevant journals. The author focuses his coverage on the biotransformation in animals, plants, and microbes while remaining within the scope of aromatic compounds that contain, or are fused with, at least one aromatic C6 ring. Part One lists each compound alphabetically along with the forward and reverse mechanisms of its metabolism in specific organisms. Part Two characterizes the different types of organic reactions that have been identified – including formation and degradation, oxidations and reductions, substitution, and transfer reactions – and the enzymes associated with those reactions. The author cites selected references for enzymes that are well documented while filling in the details for those with little research literature. This book also contains a searchable CD-ROM of the author’s previous work covering aromatic compounds researched from 1900 through 1972.
Presenting the most complete resource of its kind, this well-established author draws on his firsthand knowledge to organize a large body of information into a user-friendly and indispensable handbook for professionals, policymakers, and researchers alike.
Additional information
| Weight | 3.5 kg |
|---|
Product Properties
| Year of Publication | 2004 |
|---|---|
| Table of Contents | Alphabetical Listing of Aromatic Compounds PART 2 REACTIONS INVOLVING THE FORMATION AND DEGRADATION OF THE AROMATIC NUCLEUS Aromatization of 6-membered carbon and heterocyclic rings Formation of carbon ring systems Formation of heterocyclic ring systems Polymerization reactions Reactions involving carbon ring fission Reactions involving heterocyclic ring fission Dearomatization Ring expansion OXIDATIONS AND REDUCTIONS INVOLVING THE AROMATIC NUCLEUS AND NON-ORGANIC SUBSTITUENTS Hydroxylation of the aromatic nucleus Formation of quinones and analogues from catechols, quinols and other precursors Free radicals from phenols Oxidation of nuclear amino groups and analogues Oxidation of heterocyclic amines Reduction of nitro groups and analogues Oxidation and reduction of sulphur atoms Reduction of quinones and analogues Halogens and the aromatic nucleus Epoxide formation and reduction Deamination of arylamines without hydroxylation Dehydroxylation of phenols Nitro group addition and removal OXIDATIONS AND REDUCTIONS OF SUBSTITUENT SIDE CHAINS AND NON-AROMATIC RING SYSTEMS (WITHOUT ALTERING CHAIN LENGTH) Hydroxylation of the carbon side-chain Alkyl oxidation to ketone Oxidations and reductions of alcohols, aldehydes and ketones Reductions of acids Deamination Oxidative removal of substituents on amino groups Oxidations and reductions involving nitrogen atoms O-Dealkylation Oxidations and reductions of non-aromatic ring systems Sulphur replacement Dehydroxylation Side chain halogenation Oxidative rearrangement FORMATION AND DEGRADATION OF SIDE-CHAINS Side-Chain Formation Decarboxylation of phenolic groups without hydroxylation Decarboxylation reactions of side-chains Other reactions involving side-chain shortening and removal Chain lengthening reactions CONJUGATION AND SUBSTITUTION REACTIONS Ester formation Sulphamate formation Glycoside formation Conjugation of thiols Formation of amides and substituted amides Phosphorylation reactions Ether formation N-alkylation Silane anhydrides ELIMINATION OF SUBSTITUENTS Ester hydrolysis Hydrolysis of glycosides Hydrolysis of amides Hydrolysis of phosphates Miscellaneous reactions TRANSFER REACTIONS Transamination Isomerization Migrations Racemization FORMATION AND REACTIONS OF NON-ARYL DOUBLE AND TRIPLE BONDS Double and triple bond formation Reactions of double bonds HYDRATION OF EPOXIDES LIGHT-FORMING REACTIONS INDEX BIBLIOGRAPHY |
| Author | B.L. Goodwin |
| ISBN/ISSN | 9780415271769 |
| Binding | Hardback |
| Edition | 1 |
| Publisher | CRC Press |
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